), is an allylamine antifungal drug
that inhibits D14 reductase
and D7-D8 isomerase
, which depletes ergosterol
and causes ignosterol
to accumulate in the fungal cytoplasmic cell membranes
Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a Nail Lacquer, containing 5% Amorolfine as the active ingredient. It is currently available over the counter in the UK, having recently been re-classified from prescription-only status.
Amorolfine exhibits a broad spectrum of action, meaning that it kills a wide variety of different fungi, and when used as directed can actually cure the infection for a majority of sufferers.