The specific linkage of the correct amino acid to each tRNA is accomplished by aminoacyl-tRNA synthetases. Due to the degeneracy of the genetic code, some of the different tRNAs have the same amino acid attached to them.
Amino acid + ATP ↔ Aminoacyl-AMP + PPi
Then, the amino acid residue is transferred to the tRNA:
Aminoacyl-AMP + tRNA ↔ Aminoacyl-tRNA + AMP
The net reaction is
Amino acid + ATP + tRNA ↔ Aminoacyl-tRNA + AMP + PPi
The net reaction is only energetically favourable because the pyrophosphate is hydrolysed; that reaction is highly energetically favourable and drives the other reactions. All of these reactions take place inside the aminoacyl-tRNA synthetase specific for that tRNA.
Patent Application Titled "Combination of an Aminoacyl-TRNA Synthetase Inhibitor with a Further Antibacterial Agent for Attenuating Multiple Drug Resistance" Published Online
Sep 25, 2013; By a News Reporter-Staff News Editor at Biotech Week -- According to news reporting originating from Washington, D.C., by NewsRx...
US Patent Issued to Fundacio Privada Parc Cientific de Barcelona, Institucio Catalana de Recerca I Estudis Avanca on May 22 for "Screening Method for Identifying New Aminoacyl-Trna Synthetase Inhibitors" (Spanish Inventors)
May 27, 2012; ALEXANDRIA, Va., May 27 -- United States Patent no. 8,183,006, issued on May 22, was assigned to Fundacio Privada Parc Cientific...