D'Antonio formed the band Killswitch Engage after the demise of his band Overcast in 1998.
All of Killswitch Engage's artwork and merchandise is designed by D'Antonio, who is a graphic artist. D'Antonio's company, DarkicoN, designs and produces artwork for bands such as Shadows Fall, Unearth and All That Remains.
D'Antonio uses his signature Ibanez basses with an Mesa Boogie bass rig. In the past he used Ampeg
When at live gigs, D'Antonio will usually point out to someone in the crowd he can see enjoying themselves, or doing something unusual. On Killswitch Engage's DVD (Set This) World Ablaze, he claims to do this to raise the level of interaction with the band and the fans, and also because he feels that showing individual fans he recognises them amongst a crowd could potentially raise the 'respect' between band and fan. He also takes a long stand against racism, believing fans all over the world have a special place in his heart. He is also a vegetarian.