Aetolia-Acarnania, (Greek: Αιτωλοακαρνανία, Aitoloakarnanía, also Aetoloacarnania and Etoloakarnania) is one of the prefectures of Greece. It is located in the western part of Greece; the prefecture is a combination of the regions Aetolia and Acarnania, and its capital for historical reasons is Mesolongi, with its biggest city and economic centre at Agrinion. The area is now connected with the Peloponnese peninsula via the spectacular Rio-Antirio Bridge, and the surrounding prefectures take in Arta in Epirus, a narrow length bordering Karditsa of Thessaly, Eurytania to the northeast, and Phocis to the east. This is the largest prefecture in Greece.
Lakes include the Amvrakia, the Lysimachia, Ozeros, and Trichonida, and artificial lakes and reservoirs include Kastraki, Kremasta, also the nation's largest lake since its creation in 1970, and Stratos. Two lagoons are found in the southern part of the prefecture, the Messolongi and the Aitoliko or Etoliko
On April 11, 2007 an enormous earthquake rumbled the prefecture and was even felt in southernmost Epirus, Evrytania, Phokida, Achaia, Ilia and Lefkada including its smaller Ionian Islands, its epicenter was at Lake Trichonida and measured 5.3, 5.4, 5.6 and 5.7 on the Richter scale, the first earthquake occurred at 2 AM, the second at 6 AM and three more occurred at 10:13, 10:14 and at 10:15 AM, the last one occurred at around 10:45, about a half-hour later. It caused panic to the streets especially as residents evacuated and worried at their homes and shops at downtown Agrinio. Several houses were damaged; also one school as the wall and ceiling tumbled over desks. Fortunately no students were inside as they were enjoying their holidays.
Rainstorms pelted the area especially in 2004, 2005 and 2006. Hailstorms pummelled the prefecture on May 25, 2007 as the low-pressure system that arrived from southern and central Europe devastated crops including tomatoes, watermelons, and other crops. The hailstones were nearly the size of golfballs and turned the ground to a wintry scene.
During the Ottoman period, the modern prefecture between the 16th century until the Greek War of Independence was called a sanjak of Karleli.
A drawbridge linking the island of Lefkada began in the 1960s. The prefecture's first reservoir, the Acheloos Dam over the Acheloos was under construction in 1967 and completed in the early-1970s delivering water and hydro to western part of Greece, villages were relocated at the time. Two more dams were added, the Stratos Hydroelectric Dam in the 1980s and another in the late-1980s.
A railway formally served the places from Kryoneri and Agrinio and served with the ferry with Rio. In the 1980s, the service came to an end and was the next on the list of prefectures not connected with rail. It will remain on the list but not high speed rail which will be in plan and connect with other cities including Athens, Patras and Ioannina, the track through this prefecture remains uncertain since there is no tunnel with the Peloponnese.
| Municipality | YPES code | Seat (if different) | Postal code |
|---|---|---|---|
| Agrinio | 0202 | 302 00 | |
| Aitoliko | 0203 | ||
| Alyzia | 0204 | Kandila | |
| Amfilochia | 0205 | ||
| Anaktorio | 0206 | Vonitsa | |
| Angelokastro | 0201 | ||
| Antirrio | 0207 | ||
| Apodotia | 0208 | Ano Chora | |
| Arakynthos | 0209 | Papadates | |
| Astakos | 0210 | ||
| Chalkeia | 0229 | Tríkorfo | |
| Fyteies | 0228 | ||
| Inachos | 0213 | Néo Chalkiópoulo | |
| Kekropia | 0214 | Palairos | |
| Makryneia | 0215 | Gavalou | |
| Medeon | 0216 | Katouna | |
| Menidi | 0217 | ||
| Messolonghi also Iera Polis Messolonghi | 0218 | Messolonghi | f301 00 |
| Naupactus | 0219 | Náfpaktos | |
| Neapoli | 0220 | Elaiófyto | |
| Oiniades | 0221 | Neochori | |
| Panaitoliko | 0222 | Skoutera | |
| Parakampylia | 0224 | Ano Agios Vlasios | |
| Paravola | 0223 | ||
| Platanos | 0225 | ||
| Pyllini | 0226 | Simos | |
| Stratos | 0227 | ||
| Thermo | 0211 | ||
| Thestieis | 0212 | Kainourgio |