Over six seasons, he has played for the Celtics, Dallas Mavericks, Houston Rockets and Chicago Bulls, averaging 4.4 points, 3.3 rebounds and one steal per game.
On July 16 2006, Griffin's agent announced that he would be ending his second tenure with the Mavericks and beginning his second tenure with the Bulls. He signed a three-year contract with Chicago.
On February 21, 2008, Griffin was sent to the Seattle Supersonics in an 11-player deal that involved players from the Chicago Bulls, Cleveland Cavaliers, and Seattle Supersonics.
On August 13, 2008, he was reportedly sent to Milwaukee Bucks in a three team trade that involved players from the Cleveland Cavaliers, Milwaukee Bucks and Oklahoma City.
Griffin is married with four children.
|- | align="left" | 1999–00 | align="left" | Boston | 72 || 47 || 26.8 || .424 || .281 || .753 || 5.2 || 2.5 || 1.6 || .2 || 6.7 |- | align="left" | 2000–01 | align="left" | Boston | 44 || 0 || 8.6 || .340 || .346 || .750 || 2.0 || .6 || .4 || .1 || 2.1 |- | align="left" | 2001–02 | align="left" | Dallas | 58 || 34 || 23.8 || .499 || .296 || .837 || 3.9 || 1.8 || 1.3 || .2 || 7.2 |- | align="left" | 2002–03 | align="left" | Dallas | 74 || 48 || 18.6 || .433 || .250 || .844 || 3.6 || 1.4 || 1.0 || .1 || 4.4 |- | align="left" | 2003–04 | align="left" | Houston | 19 || 1 || 7.0 || .278 || .500 || .000 || 1.0 || .5 || .4 || .1 || .6 |- | align="left" | 2004–05 | align="left" | Chicago | 69 || 1 || 9.7 || .360 || .222 || .750 || 2.1 || .8 || .6 || .1 || 2.2 |- | align="left" | 2005–06 | align="left" | Dallas | 52 || 45 || 23.9 || .480 || .000 || .774 || 4.4 || 1.7 || 1.0 || .2 || 4.6 |- | align="left" | 2006–07 | align="left" | Chicago | 54 || 1 || 10.8 || .473 || .000 || .789 || 2.0 || 1.1 || .6 || .1 || 2.5 |- | align="left" | 2007–08 | align="left" | Chicago | 22 || 2 || 10.1 || .400 || .000 || .429 || 1.7 || 1.0 || .6 || .1 || 2.3 |- | align="left" | 2007–08 | align="left" | Seattle | 13 || 0 || 6.5 || .375 || .000 || 1.000 || 1.7 || .4 || .4 || .1 || 1.1 |- | align="left" | Career | align="left" | | 477 || 179 || 16.8 || .438 || .278 || .763 || 3.2 || 1.4 || .9 || .1 || 4.0 |}
|- | align="left" | 2001–02 | align="left" | Dallas | 4 || 1 || 14.3 || .588 || .000 || .000 || 2.3 || 1.0 || .5 || .2 || 5.0 |- | align="left" | 2002–03 | align="left" | Dallas | 15 || 2 || 8.7 || .415 || .333 || 1.000 || 2.9 || .5 || .3 || .0 || 2.5 |- | align="left" | 2004–05 | align="left" | Chicago | 5 || 0 || 17.2 || .517 || .000 || .800 || 4.0 || 1.8 || 1.0 || .0 || 6.8 |- | align="left" | 2005–06 | align="left" | Dallas | 20 || 8 || 17.5 || .542 || .000 || .875 || 3.6 || 1.2 || .8 || .1 || 3.6 |- | align="left" | 2006–07 | align="left" | Chicago | 4 || 0 || 2.3 || .000 || .000 || .000 || .3 || .0 || .2 || .0 || .0 |- | align="left" | Career | align="left" | | 48 || 11 || 13.2 || .487 || .200 || .765 || 3.0 || .9 || .6 || .1 || 3.4 |}