S-adenosyl-L-homocysteine + H₂O $rightleftharpoons$ S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Thus, the two substrates of this enzyme are S-adenosyl-L-homocysteine and H₂O, whereas its two products are S-(5-deoxy-D-ribos-5-yl)-L-homocysteine and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-adenosyl-L-homocysteine homocysteinylribohydrolase. Other names in common use include S-adenosylhomocysteine hydrolase (ambiguous), S-adenosylhomocysteine nucleosidase, 5'-methyladenosine nucleosidase, S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase, and AdoHcy/MTA nucleosidase. This enzyme participates in methionine metabolism.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , and .

References

• Duerre JA "A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5-methylthioadenosine". J. Biol. Chem. 237 3737–3741.
• Ferro AJ, Barrett A, Shapiro SK "Kinetic properties and the effect of substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coli". Biochim. Biophys. Acta. 438 487–94.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes