, a ribose-5-phosphate-ammonia ligase
is an enzyme
the chemical reaction
- ATP + ribose 5-phosphate + NH3 ADP + phosphate + 5-phosphoribosylamine
The 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH3, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is ribose-5-phosphate:ammonia ligase (ADP-forming). Other names in common use include 5-phosphoribosylamine synthetase, ribose 5-phosphate aminotransferase, and ammonia-ribose 5-phosphate aminotransferase. This enzyme participates in purine metabolism.
- Reem GH "Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis". J. Biol. Chem. 243 5695–701.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes