, a long-chain-acyl-CoA dehydrogenase
is an enzyme
the chemical reaction
- acyl-CoA + acceptor 2,3-dehydroacyl-CoA + reduced acceptor
Thus, the two substrates of this enzyme are acyl-CoA and acceptor, whereas its two products are 2,3-dehydroacyl-CoA and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is long-chain-acyl-CoA:acceptor 2,3-oxidoreductase. Other names in common use include palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, long-chain acyl-coenzyme A dehydrogenase, and long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase. This enzyme participates in fatty acid metabolism and ppar signaling pathway. It employs one cofactor, FAD.
- Hall CL, Heijkenskjold L, Bartfai T, Ernster L, Kamin H "Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria". Arch. Biochem. Biophys. 177 402–14.
- HAUGE JG, CRANE FL, BEINERT H "On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl coA dehydrogenase". J. Biol. Chem. 219 727–33.
- Ikeda Y, Okamura-Ikeda K, Tanaka K "Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme". J. Biol. Chem. 260 1311–25.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes