Tlacacuitlahuatzin was the first tlatoani (ruler) of Tiliuhcan, a pre-Columbian Tepanec altepetl (ethnic state) near Tlacopan.
His daughters Miyahuaxochtzin and Matlalxochtzin married Huitzilihuitl and Tlatolzaca (respectively), sons of Acamapichtli, the first tlatoani of Tenochtitlan. Another daughter, Tlacochcuetzin, married Acolnahuacatl Tzaqualcatl, the first tlatoani of Tlacopan.
Upon his death, Tlacacuitlahuatzin was succeeded by Tzihuactlayahuallohuatzin, a son of Tezozomoc, the ruler of Azcapotzalco.