Acetaldehyde dehydrogenase (acetylating)

Malonate-semialdehyde dehydrogenase (acetylating)

In enzymology, a malonate-semialdehyde dehydrogenase (acetylating) is an enzyme that catalyzes the chemical reaction

3-oxopropanoate + CoA + NAD(P)+ rightleftharpoons acetyl-CoA + CO2 + NAD(P)H

The 4 substrates of this enzyme are 3-oxopropanoate, CoA, NAD+, and NADP+, whereas its 4 products are acetyl-CoA, CO2, NADH, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating). This enzyme is also called malonic semialdehyde oxidative decarboxylase. This enzyme participates in 4 metabolic pathways: inositol metabolism, alanine and aspartate metabolism, beta-alanine metabolism, and propanoate metabolism.


  • HAYAISHI O, NISHIZUKA Y, TATIBANA M, TAKESHITA M, KUNO S "Enzymatic studies on the metabolism of beta-alanine". J. Biol. Chem. 236 781–90.
  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
  • Yamada EW and Jakoby WB "Aldehyde oxidation. V. Direct conversion of malonic semialdehyde to acetyl-coenzyme A". J. Biol. Chem. 235 589–594.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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