Ibrahim was ordained as a deacon and later taught Arabic and Syriac, first in Pisa and then in Rome in the College of the Propaganda. In 1628, he published a Syriac grammar. Called to Paris in 1640 to assist Gay-Michel Le Jay in the preparation of his polyglot Bible, Ibrahim contributed to that work the Arabic and Latin versions of the Book of Ruth and the Arabic version of 3 Maccabees.
In 1646, Ibrahim was appointed professor of Syriac and Arabic at the Collège de France. Being invited by the Congregation of the Propaganda to take part in the preparation of an Arabic version of the Bible, Ibrahim went again in 1652 or 1653 to Rome. He published several Latin translations of Arabic works, of which the most important was the Chronicon Orientale of Ibnar-Rahib (1653), a history of the patriarchs of Alexandria.
Ibrahim engaged in an interesting controversy with John Selden about the historical grounds of episcopal polity, spurring him to publish his Eutychius vindicatus, sive Responsio ad Seldeni Origines (1661). With Giovanni Alfonso Borelli he wrote a Latin translation of the 5th, 6th and 7th books of the Conics by the geometrician Apollonius of Perga (1661).