Abby Denson was born in Illinois, and grew up in West Hartford, Connecticut.
Abby Denson released her first self published minicomic in 1996. Entitled Tough Love, it was influenced by both Japanese Manga and punk and told the story of the coming out of two gay teenagers in high school. The characters were Brian, a shy suburban boy; Chris, his kung-fu fighting boyfriend; and Julie, Brian's best friend. Abby sent a copy to XY Magazine for review; the editors at XY chose instead to serialize the comic in their publication, where it ran for a number of years, garnering Tough Love many fans. At the same time, Denson continued to release the series as a minicomic, until the story came to an end. Abby was also the illustrator for the cover of the special Survival Guide edition of XY.
In 2006, the entire series was reprinted as a graphic novel by Manic D Press, entitled Tough Love: High School Confidential. The next year, in 2007, Abby Denson won the '2007 Lulu of the Year' Award from the comics organization Friends of Lulu.
Abby Denson has also worked on several newsstand comics, such as Josie and the Pussycats, The Powerpuff Girls, Sabrina The Teenage Witch, and others. At the same time, she has continued to release her own self published comics which include the titles Dolltopia, Jamie Starr Teen Drag Queen, Deadsy Cat & Kissy Kitty, Cute Boys of the 80's, and others.
She has been in a number of bands including the all-women band Mz. Pakman, Let's Audio, Abbymatic and, most recently, The Saturday Night Things.
Abby is also a contributor to the Friends of Lulu published anthology, The Girls' Guide To Guy's Stuff, and Robert Kirby and David Kelly's The Book of Boy Trouble 2.