It then goes from Berkshire County into Franklin County, Massachusetts, running into Interstate 91 at an interchange in Greenfield and briefly runs concurrent with the interstate highway. At this point the old Route 2 becomes Route 2A and goes through downtown Greenfield. Route 2, however, exits off I-91, becoming a freeway briefly before becoming a two-lane freeway. Outside of Greenfield, Route 2A temporarily ends and merges with Route 2. Route 2 then becomes a regular two-lane surface road in Gill and through Erving though it has some grade-separated interchanges in Millers Falls at its intersection with Route 63. There is another gap in the two-lane freeway in the Erving area.
Once the road enters the Town of Orange, Route 2A resumes and breaks off Route 2. At this point Route 2 again becomes a two-lane freeway. In Orange, Route 2 runs concurrent with US 202. The road at this point enters Worcester County, Massachusetts. After its eastern interchange in Phillipston when US 202 breaks off to the north, Route 2 becomes a full four lane freeway, though not to Interstate standards in most points. It continues through Gardner and Leominster, where Interstate 190 begins, heading south to Worcester. In Leominster, Route 2 has several at-grade intersections with Oak Hill Road, Palmer Road, Mt. Elam Road, and Abbott Avenue.
Route 2 continues east to Middlesex County, Massachusetts. At this point it enters Boston's outer loop as it interchanges with Interstate 495 in Littleton. It continues as a freeway until it goes into Acton, where it runs into Piper Road and Taylor Road at a traffic light (Exit 44). At this point the freeway ends and Route 2 becomes a regular divided highway at most points and just a four lane highway at other points. At the Concord Rotary, a major traffic choke point, Route 2 intersects with Route 2A and the beginning of Route 119 (which is overlapped with 2A at that point). After the rotary the road loses its dividing wall as it passes past the State Police (who have an emergency-only traffic light) and over the Assabet River. Route 2A used to then break away from Route 2 at the next traffic light to go left into Concord but is now overlaid with Route 2. At Crosby's Corner, the sixth intersection after the rotary, Route 2A goes straight while Route 2 veers right (but still heads east). The highway loses its dividing wall until the Bedford St intersection in Lincoln where it becomes divided again. MassHighway currently expects to rebuild the Crosby Corner intersection and create a dividing wall from there to Bedford St in 2009-2011.
At this point Route 2 enters Lexington and still is a divided 4-lane road with surface intersections. It then heads to Boston's inner belt, crossing Interstate 95/Route 128. From there, Route 2 is a six-lane and then eight-lane limited access highway until Exit 60, where it narrows with little warning to six lanes and then to four lanes. This section of freeway actually meets the standards of an interstate highway. The final off-ramp leads directly to the large parking garage at the MBTA Alewife Station. At this point the road heads into Cambridge, Massachusetts.
The limited access freeway portion ends at a signalized intersection, where it merges with U.S. Route 3 south and Route 16 west in Cambridge and continues as a four-lane surface road to the Boston Public Garden. Route 2 follows Alewife Brook Parkway, Fresh Pond Parkway, Gerry's Landing Road, and Memorial Drive (all parkways maintained by the Department of Conservation and Recreation) through Cambridge. It crosses into Boston on the Boston University Bridge. After crossing Commonwealth Avenue (US Route 20), it follows Montfort Street and Beacon Street into Kenmore Square which is the eastern terminus of US Route 20. From Kenmore Square, Route 2 follows Commonwealth Avenue to Arlington Street. It circles the Public Garden in Boston, using Arlington Street to Boylston Street to Charles Street. Route 2 officially ends at Route 28 at the intersection of Charles Street and Beacon Street at the Boston Common.
|Freeway begins at I-91.|
|Greenfield|| I-91 north – Bernardston, Brattleboro, VT|
I-91 south/Route 2 west – Springfield, North Adams
|Eastbound entrance, westbound exit.|
|US 5/Route 10 – Greenfield, Bernardston|
|Freeway ends at in Greenfield, at-grade intersection.|
|Freeway resumes at in Erving, at-grade intersection.|
|Orange||14||West River Street – Orange Center|
|15||Route 122 – Orange, Worcester|
|16||US 202 south – BelchertownDaniel Shays Highway – Athol||US 202 joins eastbound and leaves westbound.|
|Athol||17||Route 32 – Athol, Petersham|
|Phillipston||18||Route 2A – Athol, Phillipston|
|19||US 202 north/Route 2A – Phillipston, Winchendon||US 202 leaves eastbound and joins westbound.|
|Templeton||20||Baldwinville Road – Templeton, Baldwinville|
|21||Route 2A/101 – Templeton, Ashburnham|
|Gardner||22||Route 68 – Gardner, Hubbardston|
|23||Gardner, South Gardner|
|Westminster||24||Route 140 north/West Main Street – Ashburnham, Winchendon||Route 140 joins eastbound and leaves westbound.|
|25||Route 2A/Route 140 south – Fitchburg, Princeton||Route 140 leaves eastbound and joins westbound.|
|26||Willard Road, Village Inn Road||Eastbound exit only.|
|27||Narrows Road, Depot Road|
|Fitchburg||28||Route 31 – Fitchburg, Princeton|
|(29)||Mount Elam Road||At-grade intersection with barrier in the middle of the road. Highway not up to freeway standards (flashing light).|
|Leominster||30||Merriam Avenue/South Street – Leominster, Fitchburg|
|31||Route 12 – Leominster, Fitchburg|
|32||Route 13 – Leominster, Lunenburg|
|33||I-190 south – Leominster, Worcester||Northern terminus of I-190|
|Lancaster||34||Mechanic Street/Harvard Street|
|35||Route 70 – Lancaster, Lunenburg|
|36||Shirley Road – Shirley|
|37B||Jackson Road – Devens Reserve Forces Training Area||No public access to Exit 37A (eastbound)|
|Harvard||38||Route 110/Route 111 – Harvard, Worcester, Ayer, Groton|
|Littleton||39||Taylor Street – Littleton, Boxboro|
|40||I-495 – Marlboro, Worcester, Lowell, Lawrence|
|Boxborough||41||Newtown Road/Central Street – West Acton, Littleton|
|Acton||42||Route 27 – Acton, Maynard|
|43||Route 111 north – West Acton||Eastbound entrance, westbound exit.|
|Freeway ends at Piper Road/Taylor Road traffic light in Acton.|
|Freeway begins just east of Lincoln-Lexington line.|
|Lexington||52||I-95/Route 128 – Attleboro, Peabody|
|53||Spring Street – Lexington, Waltham||No westbound off-ramp|
|54||Waltham Street – Lexington, Waltham||Eastbound entrance, westbound exit.|
|55||Pleasant Street – Lexington, Waltham||Eastbound exit, westbound entrance.|
|56|| Route 4/Route 225 – Lexington, Bedford|
Winter Street – Waverly
|Arlington||57||Dow Avenue – Arlmont, Arlington, Belmont|
|Arlington/Belmont||58||Park Avenue – Belmont, Arlington Heights|
|59||Route 60 – Arlington Center, Belmont Center|
|Arlington||60||Lake Street – East Arlington, Belmont|
|Cambridge||Alewife T Station||Eastbound exit only.|
|Freeway ends at US 3/Route 16 in Cambridge, at-grade intersection.|
At least two major improvements to Route 2 are planned for Concord MA over the next 5 of so years through the Boston regional Metropolitan Planning Organization.
In the early 1920s, Route 2 was known as New England Interstate Route 7 (NE-7), a major road connecting Boston with Troy, New York. NE-7 ran roughly where Route 2A (the original surface alignment of Route 2) does now except near the New York state line. NE-7 used current Route 43 (Massachusetts), New York State Route 43 and New York State Route 66 to reach Troy. Current Route 2 from Williamstown to Petersburgh was previously numbered as Route 96.
Route 2 was originally planned to continue as Boston's northwest expressway (freeway) to a junction with Interstate 695, the Inner Beltway, but this, along with the Inner Beltway itself, was cancelled in 1970, accounting for the abrupt narrowing at Alewife.
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