Places

• ACF River Basin, Apalachicola-Chattahoochee-Flint River Basin in the southeastern USA

Organizations

Conservation

• African Conservation Foundation, organisation involved with the conservation of African wildlife and habitats
• Australian Conservation Foundation, Australian non-profit organisation promoting ecological sustainability

Social welfare

• Action Against Hunger (Action Contre la Faim), international non-profit, non-governmental organisation that fights against hunger
• Administration for Children and Families, operating unit of the US Dept of Health & Human Services

Other

• Academic Competition Federation, decentralized body responsible for collegiate quizbowl events
• Active Citizen Force, temporary conscripts and volunteers in the South African Army
• Adivasi Cobra Force, extremist Santal organisation in Assam
• American Car and Foundry Company, manufacturer of railroad rolling stock since 1899, now known as ACF Industries
• American Checker Federation, a non-profit organization governing the game of American checkers in the USA
• American Culinary Federation
• Arab Chess Federation
• Army Cadet Force, British youth organisation that offers progressive military training to boys and girls aged 12 to 18
• Asian Chess Federation
• Automobile Club de France, prestigious men's club located on Place de la Concorde in Paris
• Associazione Calcio Fiorentina, is an Italian football club

Science and computing

• Advanced communication function, resource-sharing and distributed-processing software for Systems Network Architecture networks
• African clawed frog, species of South African aquatic frog of the genus Xenopus
• Algebraically closed fields, when considered together as a class of models are abbreviated ACF
• Anisotropic Conductive Film
• Autocorrelation function, mathematical tool used frequently in signal processing