Heterocyclic compounds are organic compounds containing at least one atom of carbon, and at least one element other than carbon, such as sulfur, oxygen or nitrogen within a ring structure. These structures may comprise either simple aromatic rings or non-aromatic rings. Some examples are pyridine (C5H5N), pyrimidine (C4H4N2) and dioxane (C4H8O2).
Note that compounds such as cyclopropane, an anaesthetic with explosive properties, and cyclohexane, a solvent, are not heterocyclic; they are merely cycloalkanes. The prefix 'cyclic' implies a ring structure, whereas 'hetero' refers to an atom other than carbon, as above. Many heterocyclic compounds, including some amines, are carcinogenic.
Heterocyclic chemistry is the chemistry branch dealing exclusively with synthesis, properties, and applications of heterocycles.
Heterocycles with three atoms in the ring are more reactive because of ring strain. Those containing one heteroatom are, in general, stable. Those with two heteroatoms are more likely to occur as reactive intermediates. Common 3-membered heterocycles are:
|Oxygen||Ethylene oxide (epoxides, oxiranes)||Oxirene|
|Nitrogen||Tetrahydropyrrole (azolidine, pyrrolidine)||Dihydropyrrole (pyrroline), Pyrrole|
|Oxygen||Tetrahydrofuran (oxolane)||Dihydrofuran, Furan|
|Sulfur||Tetrahydrothiophene (thiolane)||Dihydrothiophene, Thiophene|
Six membered rings with a single heteroatom:
With two heteroatoms:
|Nitrogen / oxygen||Oxazine|
|Nitrogen / sulfur||Thiazine|
Some heterocyclic amines (HCAs) found in cooked meat are known carcinogens. Research has shown that cooking certain meats at high temperatures creates chemicals that are not present in uncooked meats. For example, heterocyclic amines are the carcinogenic chemicals formed from the cooking of muscle meats such as beef, pork, fowl, and fish. HCAs form when amino acids and creatine (a chemical found in muscles) react at high cooking temperatures. Researchers have identified 17 different HCAs resulting from the cooking of muscle meats that may pose human cancer risk. NCI's Division of Cancer Epidemiology and Genetics found a link between individuals with stomach cancer and the consumption of cooked meat, and other studies for colorectal, pancreatic, and breast cancer is associated with high intakes of well-done, fried, or barbecued meats. Other sources of protein (milk, eggs, tofu, and organ meats such as liver) have very little or no HCA content naturally or when cooked.
Researchers from University of Pune Provide Details of New Studies and Findings in the Area of Physical Chemistry.
Mar 27, 2012; "The structural and electronic properties of the (Ga2O3) clusters (n = 1-10) have been studied within the framework of density...