4-hydroxyphenylacetate 3-monooxygenase

Androst-4-ene-3,17-dione monooxygenase

In enzymology, an androst-4-ene-3,17-dione monooxygenase is an enzyme that catalyzes the chemical reaction

androst-4-ene-3,17-dione + AH2 + O2 rightleftharpoons 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O

The 3 substrates of this enzyme are androst-4-ene-3,17-dione, AH2, and O2, whereas its 3 products are 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone, A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidorcockeductase (13-hydroxylating, lactonizing). Other names in common use include androstene-3,17-dione hydroxylase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstenedione monooxygenase, and 4-androstene-3,17-dione monooxygenase. This enzyme participates in androgen and estrogen metabolism.


  • Prairie RL and Talalay P "Enzymatic formation of testololactone". Biochemistry 2 203–208.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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