ATP + 4-hydroxybenzoate + CoA $rightleftharpoons$ AMP + diphosphate + 4-hydroxybenzoyl-CoA

The 3 substrates of this enzyme are ATP, 4-hydroxybenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-hydroxybenzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 4-hydroxybenzoate:CoA ligase (AMP-forming). Other names in common use include 4-hydroxybenzoate-CoA synthetase, 4-hydroxybenzoate-coenzyme A ligase (AMP-forming), 4-hydroxybenzoyl coenzyme A synthetase, and 4-hydroxybenzoyl-CoA ligase. This enzyme participates in benzoate degradation via coa ligation.

References

• Merkel SM, Eberhard AE, Gibson J, Harwood CS "Involvement of coenzyme A thioesters in anaerobic metabolism of 4-hydroxybenzoate by Rhodopseudomonas palustris". J. Bacteriol. 171 1–7.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes