(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] $rightleftharpoons$ hexadec-2-enoyl-[acyl-carrier-protein] + H₂O

Hence, this enzyme has one substrate, (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein], and two products, hexadec-2-enoyl-[acyl-carrier-protein] and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase (hexadec-2-enoyl-[acyl-carrier protein]-forming). Other names in common use include D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, beta-hydroxypalmitoyl-acyl carrier protein dehydrase, beta-hydroxypalmitoyl thioester dehydratase, beta-hydroxypalmityl-ACP dehydrase, and (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase. This enzyme participates in fatty acid biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Mizugaki M, Swindell AC, Wakil SJ "Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E coli fatty acid synthetase". Biochem. Biophys. Res. Commun. 33 520–7.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes