In terms of DTIME,
2-EXPTIME can also be reformulated as the space class AEXPSPACE, the problems that can be solved by an alternating Turing machine in exponential space. This is one way to see that EXPSPACE 2-EXPTIME, since an alternating Turing machine is at least as powerful as a deterministic Turing machine.
2-EXPTIME is one class in a hierarchy of complexity classes with increasingly higher time bounds. The class 3-EXPTIME is defined similarly to 2-EXPTIME but with a triply-exponential time bound . This can be generalized to higher and higher time bounds.
Generalizations of many fully observable games are EXPTIME-complete. These games can be viewed as particular instance of a class of transition systems defined in terms of a set of state variables and actions/events that change the values of the state variables, together with the question of whether a winning strategy exists.
A generalization of this class of fully observable problems to partially observable problems lifts the complexity from EXPTIME-complete to 2-EXPTIME-complete.