2,5-dioxopiperazine hydrolase

2,5-dioxopiperazine hydrolase

In enzymology, a 2,5-dioxopiperazine hydrolase is an enzyme that catalyzes the chemical reaction

2,5-dioxopiperazine + H2O rightleftharpoons glycylglycine

Thus, the two substrates of this enzyme are 2,5-dioxopiperazine and H2O, whereas its product is glycylglycine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 2,5-dioxopiperazine amidohydrolase. Other names in common use include cyclo(Gly-Gly) hydrolase, and cyclo(glycylglycine) hydrolase.


  • Suzuki Y and Uchida K "Multiple forms of alpha-glycosidase from pig duodenum". Agric. Biol. Chem. 49 1573–1581.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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