USS Bush (DD–166) was a Wickes-class destroyer in the United States Navy during the World War I. She was named for Lieutenant William Sharp Bush, USMC.
After her final acceptance trials in July 1919 Bush operated along the East Coast with Destroyer Squadron 3, Atlantic Fleet, until 29 November 1919 when she arrived at Charleston, South Carolina, and became a unit of Squadron 1 Flotilla 7, in reduced commission. She was in reserve status until the summer of 1920. She then engaged in conducting training cruises for Naval Reserves. Thereafter, she exercised alternately at Charleston, her winter base, and at Newport, Rhode Island, her summer base, until placed out of commission 21 June 1922 at Philadelphia Navy Yard. Bush was sold 8 September 1936.