The year 1650 in literature involved some significant events.
- Blaise Pascal's poor health forces him to retire from the study of mathematics.
- Parliament appoints a commission for the propagation and preaching of the gospel in Wales, advised by Vavasor Powell.
- Despite the official prohibition against stage plays, theatrical manager and promoter William Beeston finances repairs to the Cockpit Theatre and attempts to assemble and train a company of young actors. His effort is unsuccessful.
- Plagiarist Robert Baron publishes his Pocula Castalia, stealing mainly from the minor poems of John Milton issued in 1645.