The year 1603 in science and technology involved some significant events.

Astronomy

• Johann Bayer publishes the star atlas Uranometria.

Exploration

• The first successful French colony in North America, Acadia, is founded.

General

• Accademia dei Lincei, the oldest scientific academy in the world, is founded in Rome by Federico Celesi.

Medicine

• Girolamo Fabrici studies leg veins and notices that they have valves which only allow blood to flow toward the heart.

Births

• Abel Tasman, explorer (died 1659)

Deaths

• François Viète, mathematician. (born 1540)