Events

• January 25 - Alfonso II becomes King of Naples.
• May 3 - Christopher Columbus first spots Jamaica.
• May 31 - First Battle of Acentejo: Natives of the island of Tenerife, known as Guanches, defeat the invading Spanish forces.
• June 7 - Treaty of Tordesillas: Spain and Portugal divide the New World between themselves.
• October 22 - Ludovico Sforza becomes Duke of Milan, and starts a chain of events that leads to the First Italian War.

Undated

• Amda Seyon II succeeds his father Eskender as Emperor of Ethiopia.
• Na'od succeeds his nephew Amda Seyon II as Emperor of Ethiopia.
• Aztec forces conquer and sack Mitla.
• Italy is invaded by Charles VIII of France.

Births

• February 2 - Bona Sforza, queen of Sigismund I of Poland (d. 1557)
• April 9 - Francois Rabelais, French Renaissance writer (d. 1553)
• April 20 - Johannes Agricola, German Protestant reformer (d. 1566)
• May 24 - Pontormo, Italian painter (d. 1557)
• September 5 - Hans Sachs, German Meistersinger (d. 1576)
• September 12 - King Francis I of France (d. 1547)
• November 6 - Suleiman the Magnificent, Ottoman Sultan (d. 1566)
• date unknown
• Saitō Dōsan, Japanese warlord (d. 1556)
• John Sutton, 3rd Baron Dudley (d. 1554)
• Juan Ginés de Sepúlveda, Spanish philosopher and theologian (d. 1573)
• Ambrosius Holbein, German painter (d. 1519)
• Alonso Álvarez de Pineda, Spanish explorer and cartographer (d. 1519)
• Hans Tausen, Danish religious reformer (d. 1561)
• Qiu Ying, Chinese painter (d. 1552)
• William Tyndale, English reformer and martyr (d. 1536)

Deaths

• January 11 - Domenico Ghirlandaio, Italian artist (b. 1449)
• January 25 - King Ferdinand I of Naples (b. 1423)
• August 1 - Giovanni Santi, artist and father of Raphael (b. c. 1435)
• August 11 - Hans Memling, Flemish painter (b. c. 1430)
• September 24 - Poliziano, Italian humanist (b. 1454)
• October 26 - Amda Seyon II, Emperor of Ethiopia (b. c. 1487)
• November 8 - Melozzo da Forlì, painter (b. c. 1438)
• November 17 - Giovanni Pico della Mirandola, Italian humanist (b. 1463)
• December 20 - Matteo Maria Boiardo, Italian poet (b. c. 1434)
• date unknown
• Eskender, Emperor of Ethiopia (b. 1472)