The western part of the street runs diagonally between the neighborhoods of Manhattanville and Morningside Heights from the north-west from an interchange with the Henry Hudson Parkway at 130th Street. East of Morningside Avenue it runs east-west through central Harlem to an interchange with F.D.R. Drive by the East River, where it becomes the Manhattan leg of the Triborough Bridge. Many sections of the street have been gentrified and developed with such stores as Old Navy, H&M, CVS/pharmacy, and Magic Johnson Theaters. The historic Apollo Theater is here. In collaboration with the community, the city has developed a plan for the 125th Street corridor focusing on reinforcing and building upon its strengths as an arts and cultural corridor.
West of Convent Avenue, 125th Street was re-routed onto the old Manhattan Avenue. The original 125th Street west of Convent Avenue was swallowed up to make the super-blocks where the low income housing projects now exist. What remains of the original alignment of 125th Street is called La Salle Street, which runs between Amsterdam Avenue and Claremont Avenue.