11-cis-retinyl-palmitate hydrolase

In enzymology, a 11-cis-retinyl-palmitate hydrolase is an enzyme that catalyzes the chemical reaction

11-cis-retinyl palmitate + H2O rightleftharpoons 11-cis-retinol + palmitate

Thus, the two substrates of this enzyme are 11-cis-retinyl palmitate and H2O, whereas its two products are 11-cis-retinol and palmitate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 11-cis-retinyl-palmitate acylhydrolase. Other names in common use include 11-cis-retinol palmitate esterase, and RPH. This enzyme participates in retinol metabolism. This enzyme has at least one effector, Bile salt.


  • Blaner WS, Das SR, Gouras P, Flood MT "Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells". J. Biol. Chem. 262 53–8.
  • Blaner WS, Prystowsky JH, Smith JE, Goodman DS "Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities". Biochim. Biophys. Acta. 794 419–27.

External links

Gene Ontology (GO) codes

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