1, 2, 3, 4

(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

In enzymology, a (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline rightleftharpoons S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

Thus, the two substrates of this enzyme are S-adenosyl methionine and (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline, whereas its two products are S-adenosylhomocysteine and N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This enzyme is also called norreticuline N-methyltransferase. This enzyme participates in alkaloid biosynthesis i.


  • Frenzel T, Zenk MH "Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures". Phytochemistry 29 3491–3497.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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