iron overload

Iron overload disorder

In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.


The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).

Primary iron overload

Description OMIM Mutation
Haemochromatosis type 1: "classical"-haemochromatosis HFE
Haemochromatosis type 2A: juvenile haemochromatosis hemojuvelin ("HJV", also known as HFE2)
Haemochromatosis type 2B: juvenile haemochromatosis hepcidin antimicrobial peptide (HAMP) or HFE2B
Haemochromatosis type 3 transferrin receptor-2 (TFR2 or HFE3)
Haemochromatosis type 4/
African iron overload
ferroportin (SLC11A3/SLC40A1)
Neonatal haemochromatosis (unknown)
Aceruloplasminaemia (rare disease) ceruloplasmin
Congenital atransferrinaemia (rare disease) transferrin

Secondary iron overload


The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa ()

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