Doc Samson – The Hulk's occasional psychiatrist. An ethical gamma-powered strongman with a working knowledge of nuclear biology, and excellent, quick-thinking, fighting skills.
Doctor Strange - The greatest sorcerer on Earth, and leader of the Defenders. He had an almost fatherly relationship with the rampaging Hulk, and sometimes let the latter live in his mansion. However, in recent years the two have had a falling out following the Illuminati's launching of the Hulk into space.
Falcon – Sam Wilson. He has defended the Hulk on a few occasions due to the Hulk's comforting his nephew, Jim Wilson, during his last moments alive, and financing a medical fund to honour the latter's memory.
Fred Sloan – A long-haired musician who befriended the Hulk many years ago.
Jarella – The queen of the planet K'ai and beloved of both the Hulk and Bruce Banner. Deceased due to saving a child from a falling building.
Jim Wilson – A friend of Bruce Banner and sometime sidekick. He was the first character in mainstream comics to be HIV positive. Deceased due to AIDS.
Tony Stark/Iron Man - Bruce Banner's, friend, who battles the Hulk with his Hulkbuster armor and tries to cure Bruce of the Hulk.
Kate Waynesboro - Bruce Banner's lab assistant and love interest, revealed as an agent and spy for S.H.I.E.L.D, but genuine in her affection, and remaining a friend afterwards. She has recently appeared in World War Hulk Aftersmash: Warbound.
Mastermind Excello - Amadeus Cho, allegedly the seventh smartest person on the planet. He sympathises with the Hulk after he saved him from his pursuers.
Mogol - An android constructed by Tyrannus to befriend the Hulk and enlist him as an ally, but unaware of his programming or artificial nature. Destroyed when Hulk found out and mistakenly thought that Mogol had intentionally betrayed him.
Sentry - Robert Reynolds. He is capable of pacifying the Hulk via empathy and/or a form of radiation, greatly reducing his rage-fueled power in the process. Hulk even served as his partner for a short time.
She-Hulk – Jennifer Walters, Bruce Banner's cousin, to whom he gave an emergency blood transfusion when she was critically wounded.
Silver Surfer - A godlike cosmic wanderer of great compassion and spirituality. A fellow loner, recurrent ally and occasional confidante.
Skaar - The Hulk's son. Skaar's mother is Caiera. However, Skaar has yet to encounter his father, and the Hulk is unaware that Skaar survived his mother's death.
Ulysses - A slow-aging former 50's biker rebel, and Pantheon warrior, using a very formidable glowing sword and shield.
Valkyrie - The greatest among Asgardian warrior-women, and a fellow Defender, who comforted the Hulk after Jarella's death.
Caiera, the oldstrong - The Hulk's warrior queen, with an "oldstrong" heritage, granting her the ability to turn harder than stone and attain immense levels of physical strength. Deceased in the explosion that destroyed Sakaar.
Elloe Kaifi - Daughter of a high ranking Sakaaran official whom the Red King tries for treason.
Hiroim, the Shamed - A warrior-mystic "Shadow Priest" who was expelled from his order for the heresy of believing he could be the Sakaarson, the fabled savior of planet Sakaar. He inherited Caiera's mystic Oldstrong power after all other members of his race perished.
Korg - A stone man of the Kronan race with great superhuman strength, who once fought Thor.
Miek, the unhived - A meek insectoid who becomes king of his freed people before metamorphosing into a behemoth. Although he was part of the Warbound and considered himself a friend of the Hulk, he also allowed the death of the Hulk's wife and many others on Sakaar.
No-Name of the Brood - Sole survivor of a pack of Brood warriors that landed on Planet Sakaar. Unlike most other members of her race she has the capacity for compassion.
Enemies and opponents
Abomination – Emil Blonsky. A gamma-spawned monstrous powerhouse. The Hulk's primary physical rival.
Absorbing Man - Crusher Creel. Able to magically "absorb"/duplicate the properties/powers of things/people he touches.
Agamemnon - The immortal former leader of the Pantheon, and alleged descendant of a god, turned weary, bored and immensely cynical from his millennia of existence. Cyclically building and destroying civilisations as a personal hobby.
Ajax - An immensely strong childlike bruiser, and member of the Pantheon. Like the Hulk his power increases with his rage, and he has considered the latter as a friend in the past.
Agent Pratt- a malicious calculating operative working for a secret government agency called Home Base. He has a genetic ability to regrow limbs upon death. Quotes Stephen Hawking and appears to be a genius.
Amphibion - Qnax. The sometimes ally, sometimes enemy, warrior champion of the planet Xantares, with great superhuman strength.
Armageddon - Warlord of the star-spanning troyjan empire, with power rivalling the Silver Surfer's. He holds a grudge against the Hulk for accidentally slaying his son Trauma.
Bi-Beast - A giant two-headed android living on a floating island in the sky, and containing the knowledge of the bird people that built it.
Jackdaw - The Leader's former second-in-command, who ultimately turned against him.
Brian Banner - Bruce Banner's abusive father, and the murderer of his mother. Deceased when assaulting Bruce, due to a self-defence accident, but pestering him as a vengeful ghost in more recent years.
Collector - A billions of years old being, who keeps himself active by scouring the Universe for unusual additions to his planetary collections of creatures and artefacts.
Flux – A soldier, exposed to a gamma bomb detonation by General Ryker. Deceased.
Galaxy Master – A shapeshifting alien weapon and conqueror, destroying any intelligent life that it considers a potential threat.
Gamma Corps - A series of mutated superhuman military operatives with personal grudges, originally employed by General John Ryker.
Glenn Talbot – Betty Ross' ex-husband, a military officer who tried to kill Bruce Banner and destroy the Hulk. Deceased.
Glob - A shambling bog-monster, with high resistance to physical harm.
Glorian - The reality-warping apprentice of the Shaper of Worlds has come on a collision course with the Hulk during the course of his lessons.
Grey Gargoyle - A superstrong thief and mercenary, able to turn others to stone with a touch. The Hulk's healing factor fought off the transformation.
Halflife – Anthony Masterson, a gamma-irradiated power-leech. Dead during the day, and alive during the night. Deceased.
Hammer and Anvil - An embittered African-American, and a caucasian supremacist. Escaped convicts permanently shackled to each other by a chain granting them both great physical power, and bonding their life-forces together. Deceased.
Hulkbusters - Various incarnations of military units dedicated to putting the Hulk down.
Humanoids - The Leader's army of super-strong rubber-men, virtually immune to blunt impacts, shown to include the Hulk's fists or Thor's hammer, but they are comparatively easy to immobilise or destroy with energy-based attacks.
John Ryker - A ruthless military general, who is hunting the Hulk to seek a cure for his wife.
Juggernaut- A super-strong, nearly indestructible villain whose power rivals that of the Hulk's.
Kang - A temporal tyrant of a thousand timelines, with futuristic armies at his beck and call.
Leader – A Gamma-irradiated genius with superhuman intelligence and mind-control abilities. The other Archenemy of the Hulk.
Madman - The Leader's brother, a chaotic, distorted, and clever powerhouse.
Maha Yogi - An ancient mutant and sorcerer with various psychic powers.
Maestro - A barbaric and crafty future version of the Hulk. He’s stated as twice as strong as the ‘merged’ incarnation, and is an experienced, ruthless and dishonourable combatant.
Man Beast - A wolf evolved to the height of lupine potential. A superstrong malevolent schemer with great psychic powers.
Man-Thing - Ted Sallis. Another shambling swamp-monster driven entirely by instinct. Whatever knows fear burns at his touch.
Matt Talbot - The nephew of Glenn Talbot, and an old friend of Cathy St. Lawrence. He wanted to avenge his uncle by hunting down the Hulk, but was diagnosed with cancer.
Mephisto - An immensely powerful demon who has tried to corrupt and claim the Hulk's spirit.
Mercy - An enigmatic immortal with multiple powers, including shapeshifting, draining, teleportation, energy-projection, invisibility, astral projection, and self re-assembly. She considers herself on a mission of "mercy" to "help" those who wish to die but don't have the strength to commit suicide.
Metal Master - Hulk's first superhuman adversay. An alien conqueror with practically limitless ability to control all froms of metal.
Missing Link - A radioactive monster with immense strength, a childlike personality, and the ability to reform itself after being destroyed.
Mister Hyde - A savage, super-strong, dark mirror of the Hulk.
MODOK - His name is an acronym for Mental Organism Designed Only for Killing. He possesses vast offensive psionic powers and computing intelligence, and is the leader of Advanced Idea Mechanics
Moonstone - An utterly amoral criminal psychiatrist, with super-strength, force-blasts, intangibility, flight, and capable of quickly coercing mental breakdowns.
Nightmare - An immensely powerful dream demon, who drove the Hulk mad many years ago, and distorted his reality in recent years.
Omnibus - The Leader's supergenius second in command, and briefly serving as a host for his spirit. Deceased.
Pantheon - A pro-active organisation of super-powered beings descended from the immortal Agamemnon, and titled after the participants in the Trojan War.
Paris - A manipulative empath, and brief leader of the Pantheon, with grudges against both the Hulk and Ulysses.
Piecemeal - A monster engineered from an unwilling scientist, at the Red Skull's behest, mixing up the attributes of any superbeings it encounters.
Psyklop - An humanoid insect scientist-mystic, worshipping a race of elder gods and seeking to use the Hulk as a power-source to revive them. Deceased.
Puffball Collective – An alien group-mind that kept Hulk company during his exile to the crossroads dimension. Eventually revealed as an agent of the N'Garai.
Ravage - A gamma induced monster, created by Professor Geoffrey Crawford's attempts to cure himself of a crippling disease using his Matter Teleportation Device.
Red Hulk - The Hulk's most recent antagonist. Appearing out of nowhere, The Red Hulk murders Abomination and attempts to destory Hulk, but is interrupted by Thor, whom the Red Hulk bests in sigle combat. Identity currently unknown.
Red King – The despotic emperor of the planet Sakaar, dethroned and killed by the Hulk and his Warbound.
Rhino- A Rhinoceros-based villain with super strength, speed, and tough hide like a rhino.
Riot Squad - A superpowered unit of the Leader's henchmen, and citizens of his Arctic-based utopia, Freehold.
Rock and Redeemer - A morphing boulder, capable of severely damaging even the Hulk, and an armored living weapons arsenal. Two of the Leader's main enforcers and former members of the Hulkbusters.
Sabra - A super-strong, combat expert, Israeli heroine, with a cloak emitting powerful 'energy-quills', who has recurrently come to blows with the Hulk due to misunderstandings.
Shanzar - Sorcerer supreme of the strange matter universe. He got tired of protecting his reality from threats and eradicated every sentient being in it, but eventually grew bored and decided to seek out and conquer other realms.
Space Parasite - An alien conqueror with virtually unlimited ability to absorb energy.
Speedfreek wears a power-armour granting him superhuman speed, durability and adamantium weaponry. Deceased.
Spider-Man - Peter Parker, a man bitten by a radioactive spider. Usually, he use his speed, agility and tactical ability to contrast Hulk's brute force.
Sub-Mariner - Namor McKenzie. The proud imperial ruler of the world's oceans, and a grudging recurrent ally, but their respective hot tempers have created a strong rivalry and many confrontations over the years.
Super Skrull - An alien with all the powers of the Fantastic Four. Hulk's evaluation read: "Your fire can't hurt me, your stretching's a joke, and as for your strength, well... pardon me for not being impressed by an ersatz Thing."
Thaddeus Ross – Betty Ross' father, a military general who used to hunt for the Hulk.
Thing - Ben Grimm, a member of the Fantastic Four, and a frequent rival of the Hulk's, due to consistently being defeated at his hands. They have nonetheless come to understand each other.
Thor – The god of thunder and Hulk's main rival among other superheroes, with many inconclusive confrontations over the years.
Toad Men - Short, squat-faced aliens with magnetic weaponry, and delusions of conquest. Once devastated Washington D.C., killing many military pilots.
Trauma - Prince of the Troyjans. An immensely strong warrior, with force-blasts capable of cutting through planets. Deceased.
Tyrannus – An ancient Roman would-be world conqueror, and long-time Hulk villain.
U-Foes - A Fantastic Four counterpart. They blame the Hulk for interrupting the experiment that granted them their powers.
Wendigo - A large cannibalistic monster from the Canadian north woods.
Wildman - An unpredictable scrawny lunatic, in pink bunny slippers, who can temporarily 'borrow' the abilities of the main superheroes on Earth, but is limited to one at a time.
Wolverine - Logan/James Howlett, a mutant with nearly unbreakable adamantium claws and skeleton, world-class fighting skills, and murderous psychotic rages.
Xemnu the Titan - An alien with superhuman strength, and vast psionic powers, capable of engineering formidable genetic monstrosities.
Zzzax – Electricity-based villain/monster with superhuman strength and the ability to incinerate almost anything it touches. It gains intelligence by feeding on the minds of human beings.